Key result
Moderate baseline GGT levels linked to ~1-point lower post-PCI heart failure risk.
Why the study?
Whether serum γ-glutamyl transferase level has a predictive role for heart failure after percutaneous coronary intervention remains unclear.
Cohort (n=5,638)
Absolute Event Rate: 2% vs 3.3%
p-value: p=0.046
Moderate GGT levels should not yet inform post-PCI HF risk stratification; hypothesis-generating U-shaped association requires prospective validation.
Objective: Previous studies suggested that elevated serum γ-glutamyl transferase (GGT) level is an independent predictor of coronary artery disease (CAD) and heart failure (HF). However, whether serum GGT level has a predictive role for HF after percutaneous coronary intervention (PCI) remains unclear. This study aimed to evaluate the association of GGT with HF after PCI in a Chinese population. Methods: Five thousand six hundred thirty-eight patients were divided into three groups according to GGT tertiles: first tertile (GGT <19.6 U/L; n = 1875), second tertile (GGT ≥19.6–32.9 U/L; n = 1880), and third tertile (GGT ≥32.9 U/L; n = 1883). There were 165 (2.9%) HFs during a long-term follow-up. The average follow-up time was 35.9 ± 22.6 months. Results: The incidence of HF in the first tertile is 62 (3.3%), second tertile is 38 (2.0%), and third tertile is 65 (3.5%). The HF incidence was significantly lower in second tertile compared with that in the first tertile or in the third tertile (both P < 0.05). A U-shaped curve was observed according to quintiles (Q1:3.4%, Q2: 3.0, Q3:1.6%, Q4: 2.9%, Q5: 3.7%, P = 0.042). The multivariate Cox proportional hazards model showed after adjustment of confounders, the association remains significant (P = 0.046). Conclusions: This study indicated that serum GGT concentration was independently associated with HF after PCI. The baseline serum GGT level less than 19.6 or ≥32.9 increases HF risk in CAD patients who underwent PCI.
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Zheng et al. (2019) conducted a cohort in Heart Failure after PCI (n=5,638). Serum γ-Glutamyl Transferase (GGT) level vs. Low (<19.6 U/L) or high (≥32.9 U/L) GGT tertiles was evaluated on Heart failure (HF) incidence (p=0.046). Moderate baseline serum GGT levels (19.6-32.9 U/L) were associated with a lower risk of heart failure after PCI compared to levels <19.6 or ≥32.9 U/L (2.0% vs 3.3% and 3.5%; P<0.05).
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