Key result
Ion permeation through BTX-modified Na+ channels from rat skeletal muscle can be simulated by a three-barrier, two-site model that includes double occupancy and ion-ion repulsion.
An Eyring-type model with three barriers and two sites (3B2S) successfully simulates ion permeation through batrachotoxin-modified Na+ channels, reconciling features of single and multiple ion occupancy.
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No immediate clinical implications; leaves open extension of 3B2S models to native human channels.
Ravindran et al. (1992) studied this question. Batrachotoxin (BTX) modification was evaluated on Unitary conductance and ion permeation behavior. Ion permeation through BTX-modified Na+ channels from rat skeletal muscle can be simulated by a three-barrier, two-site model that includes double occupancy and ion-ion repulsion.
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