Key result
CRISPR-Cas9 targets and cleaves foreign DNA to defend against phages and plasmids.
Key points are not available for this paper at this time.
Design
Other
Outlines bacterial CRISPR-Cas9 mechanism; leaves open therapeutic translation in cardiovascular gene editing.
Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific ...
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Pipberger et al. (1975) studied this question. CRISPR-Cas systems employ the dual RNA-guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific modifications.
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