Key result
Treatment with 17 beta-estradiol significantly attenuated the hypoxic vasomotor response in isolated lungs from both 2-month-old female and 6-month-old castrated male sheep.
The gender difference in the hypoxic stimulus-response relationship in sheep lungs arises at puberty and may be mediated by estradiol.
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Juvenile sheep lungs lack sex differences in hypoxic vasoconstriction; leaves open whether pubertal estradiol attenuation influences human pulmonary vascular responses.
Wetzel et al. (1984) studied Hypoxic vasomotor response. 17 beta-estradiol vs. Untreated/baseline was evaluated on Steady-state stimulus-response relationship of the pulmonary circulation to graded hypoxia. Treatment with 17 beta-estradiol significantly attenuated the hypoxic vasomotor response in isolated lungs from both 2-month-old female and 6-month-old castrated male sheep.
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