Key result
Pulmonary artery rings from proestrus female rats demonstrated an attenuated vasoconstrictor response to KCl compared with estrus/diestrus females (75.58% vs. 92.43%, P<0.01).
Population
Isolated pulmonary artery rings from proestrus females, estrus and diestrus females, and male Sprague-Dawley…
Comparison
Proestrus phase (high endogenous estrogen) vs Estrus/diestrus phase and male rats
Design
Preclinical
Authors
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Sex and menstrual cycle may modulate PA vasoreactivity; leaves open translation to human pulmonary hypertension.
Absolute Event Rate: 75.58% vs 92.43%
p-value: p=<0.01
Physiological increases in circulating estrogen levels during the estrous cycle attenuate pulmonary artery vasoconstriction under both normoxic and hypoxic conditions in a rat model.
Lahm et al. (2007) studied this question. Proestrus phase (high estrogen) vs. Estrus/diestrus phase and males was evaluated on Vasoconstrictor response to KCl under normoxic conditions (p=<0.01). Pulmonary artery rings from proestrus female rats demonstrated an attenuated vasoconstrictor response to KCl compared with estrus/diestrus females (75.58% vs. 92.43%, P<0.01).
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