Key result
Exercise treadmill testing unmasks diagnostic Type 1 Brugada patterns during early recovery.
Why the study?
Establishing the diagnosis of Brugada syndrome is challenging due to the often transient diagnostic ECG pattern, and alternative provocative methods are needed.
Does exercise treadmill testing provoke a Type 1 Brugada pattern in susceptible patients?
Case Report (n=3)
Does exercise treadmill testing provoke a Type 1 Brugada pattern in susceptible patients?
Exercise treadmill testing may serve as a useful diagnostic aid to provoke a concealed Type 1 Brugada ECG pattern, particularly during the early recovery phase.
Caution against routine diagnostic use of exercise testing in Brugada syndrome; leaves open its utility pending prospective validation.
Background: gene, most implicated in heritable BrS, is found in only 20% of those who have the clinical phenotype seen with BrS. Establishing the diagnosis of BrS can be challenging as the electrocardiogram (ECG) pattern that is diagnostic for the syndrome is often transient. Typically, a pharmacological challenge using a Class 1 antiarrhythmic is used to provoke a Type 1 Brugada pattern on ECG that may otherwise be concealed. Case summary: We describe a case series of three unrelated patients who underwent an exercise treadmill test (ETT) according to standard Bruce protocol. Each patient demonstrated a Type 1 Brugada pattern most apparent in the early recovery phase immediately after peak exercise but not at baseline. Discussion: This case series highlights the value of ETT as a diagnostic aid for BrS. We suggest that ETT could be considered as a routine means of provoking a Brugada ECG pattern.
No takes yet. Share an insight, caveat, or question.
A 2025 study conducted a case report in Brugada syndrome (n=3). Exercise treadmill test (ETT) was evaluated on Provocation of Type 1 Brugada pattern on ECG. Exercise treadmill testing provoked a Type 1 Brugada pattern in the early recovery phase in 3 unrelated patients, suggesting its potential as a routine diagnostic aid for Brugada syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: