Key result
Injection of 6-OHDA into the PVN prevented stress-induced increases in renin and corticosterone, while the beta-blocker sotalol prevented only the corticosterone increase.
Intact catecholaminergic innervation in the PVN is necessary for stress-induced increases in renin and corticosterone, with corticosterone specifically mediated by beta-adrenoceptors.
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No immediate clinical implications; leaves open translational relevance of PVN catecholamines to human stress responses.
Morton et al. (2008) studied Stress-induced neuroendocrine response. 6-hydroxydopamine (6-OHDA) and sotalol injections into the PVN was evaluated on Plasma renin activity (PRA), plasma renin concentration (PRC), and plasma corticosterone concentration. Injection of 6-OHDA into the PVN prevented stress-induced increases in renin and corticosterone, while the beta-blocker sotalol prevented only the corticosterone increase.
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