Key result
Bilateral electrolytic lesions or ibotenic acid injections in the hypothalamic paraventricular nucleus prevented stress-induced increases in renin and corticosterone secretion.
Neuronal cell bodies in the hypothalamic paraventricular nucleus are essential for mediating stress-induced renin and corticosterone secretion.
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PVN lesions block stress renin release; leaves open whether this circuit can be targeted in human stress-related hypertension.
Morton et al. (2008) studied Stress-induced renin and corticosterone secretion. Bilateral electrolytic lesions or ibotenic acid injections in the PVN was evaluated on Stress-induced increase in plasma renin activity (PRA), plasma renin concentration (PRC), and corticosterone levels. Bilateral electrolytic lesions or ibotenic acid injections in the hypothalamic paraventricular nucleus prevented stress-induced increases in renin and corticosterone secretion.
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