Key result
Specific lesion of NK1-expressing PVN neurones blunted the stress-induced increase in the LF/HF ratio (0.83 to 0.93, P>0.05) compared to control rats (0.84 to 2.02, P<0.05).
Absolute Event Rate: 0.93% vs 2.02%
p-value: p=>0.05
NK1-expressing PVN neurones are involved in coupling the cardiovascular system to daily heart rate variation and the sympathetic response to psychological stress in rats.
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Supports role for NK1-expressing PVN neurones in rat sympathetic stress responses; leaves open human translation.
Feetham et al. (2014) studied Healthy (investigating cardiovascular control) (n=6). SSP-SAP lesion of NK1-expressing PVN neurones vs. 50 nL PBS (control) was evaluated on Change in LF/HF ratio (indicator of sympathetic activity) in response to mild psychological stress (p=>0.05). Specific lesion of NK1-expressing PVN neurones blunted the stress-induced increase in the LF/HF ratio (0.83 to 0.93, P>0.05) compared to control rats (0.84 to 2.02, P<0.05).
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