Key result
Cigarette smoking is linked to elevated peroxynitrite levels preceding reduced nitric oxide and inflammation.
Why the study?
Oxidant components of cigarette smoke reduce nitric oxide production and/or inhibit its function, but early serum markers reflecting smoking impact are unclear.
Does chronic cigarette smoking alter serum levels of nitric oxide, peroxynitrite, and C-reactive protein in male subjects?
Cross-Sectional (n=70)
Does chronic cigarette smoking alter serum levels of nitric oxide, peroxynitrite, and C-reactive protein in male subjects?
Serum peroxynitrite (ONOO) is significantly elevated in smokers compared to non-smokers, suggesting it may serve as an early biomarker of smoking-induced oxidative stress before NO decline or systemic inflammation occurs.
Elevated peroxynitrite may mark early oxidative stress in smokers; leaves open its value as a biomarker before larger studies confirm.
Background: Nicotine dependence is a chronic and relapsing disease. Oxidant components of cigarette smoke reduce nitric oxide (NO) production and/or inhibit its function. Objectives: The aim of this study was to assess serum NO, peroxynitrite ONOO and C-reactive protein in smoker individuals using the Fagerström test for nicotine dependence. Materials and Methods: A total number of 50 male smoker subjects and 20 non-smoker subjects serving as controls were recruited in this study. The Fagerström test of nicotine dependence was used to assess the level of nicotine dependence. Venous blood was obtained from each subject and serum was separated for the following tests: C-reactive protein, NO and ONOO. Results: The mean values of C-reactive proteins in the smokers were less than 6 mg/L and there was no significant difference in the C-reactive protein level between levels of nicotine dependence according to the Fagerström test scoring. A non-significant low serum NO level was observed in smokers, which did not correlate with C-reactive protein. A significant high serum ONOO level was observed in smokers compared with non-smoker subjects, which did not correlate with C-reactive protein. Conclusions: The study concludes that serum ONOO level may serve as an initial marker to point the impact of smoking on human beings. Its elevation preceded the decline in serum NO level and the evidence of inflammation.
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Al-Nimer et al. (2012) conducted a cross-sectional in Nicotine dependence (n=70). Cigarette smoking vs. Non-smokers was evaluated on Serum peroxynitrite (ONOO) level. Cigarette smoking was associated with significantly higher serum peroxynitrite levels compared with non-smokers, which preceded the decline in serum nitric oxide and evidence of inflammation.
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