Key result
Constitutive Nrf2 activation alters 560 myocardial proteins in a murine reductive stress model.
Why the study?
Reductive stress induced by constitutively active Nrf2 affects myocardial proteome and contributes to cardiomyopathy, but specific protein signatures are not well defined.
TMT proteomic analysis in a transgenic mouse model of reductive stress cardiomyopathy identified significant alterations in stress-related pathways and a negative correlation between ~50% of altered proteins and their transcript levels.
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RS protein signature in CaNrf2-TG mice is hypothesis-generating; leaves open translational relevance to human cardiomyopathy.
Sunny et al. (2022) studied Reductive stress cardiomyopathy. Constitutively active Nrf2 (CaNrf2-TG) expression vs. Non-transgenic (NTg) mice was evaluated on Differentially expressed proteins in heart tissues. Transgenic mice expressing constitutively active Nrf2 exhibited significant alterations in the myocardial proteome, with 560 differentially expressed proteins compared to non-transgenic mice.
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