Why the study?
Excessive antioxidant generation leads to reductive stress, but how chronic reductive stress caused by constitutive Nrf2 activation drives pathological myocardial remodeling was not elucidated.
Does chronic reductive stress induced by sustained antioxidant signaling cause pathological cardiac remodeling and diastolic dysfunction in mice?
Population
caNrf2-TG (TGL and TGH) mice and nontransgenic littermates
Comparison
caNrf2-TG mice vs nontransgenic littermates, and BSO treatment vs untreated in TGH mice
Design
Preclinical animal study
Follow-up
Up to 18 months
Authors
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Reductive stress may promote cardiomyopathy; hypothesis-generating and should not yet change antioxidant practice in HF.
Does chronic reductive stress induced by sustained antioxidant signaling cause pathological cardiac remodeling and diastolic dysfunction in mice?
Chronic reductive stress from sustained antioxidant signaling causes pathological cardiomyopathy and diastolic dysfunction in mice, highlighting the need to evaluate redox state before antioxidant therapy in heart failure.
Shanmugam et al. (2020) studied this question.
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