Population
Nontransgenic and hR120GCryAB transgenic mice in C57BL/6 background assessed at 3 and 6 months of age.
Comparison
Heart-specific overexpression of human mutant… vs Nontransgenic (NTG) mice
Design
Preclinical
Follow-up
3 and 6 months of age
Authors
Loading...
May promote cardiomyopathy via reductive stress in protein aggregation models; leaves open clinical relevance of Nrf2 targeting.
Sustained activation of the Nrf2-Keap1 pathway and subsequent nuclear translocation of Nrf2 contributes to reductive stress in a mouse model of protein aggregation cardiomyopathy.
Rajasekaran et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: