Key result
ACE2 expression was highest in the small intestines, salivary glands, testis, kidney, heart, thyroid, and adipose tissues, with no significant differences in expression based on sex.
Population
RNAseq transcriptome data from 6,738 normal tissues (GTEx database) and 618 tumor tissues (TCGA database)
Authors
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ACE2 expression atlas warrants no clinical practice changes; leaves open functional validation for organ tropism and targeted interventions.
Observational (n=7,356)
ACE2 is highly expressed in specific human tissues including the small intestine, kidney, and heart, without sex differences, identifying potential target organs for SARS-CoV-2.
Han et al. (2020) conducted an observational in COVID-19 (n=7,356). Tissue type and sex was evaluated on ACE2 expression levels. ACE2 expression was highest in the small intestines, salivary glands, testis, kidney, heart, thyroid, and adipose tissues, with no significant differences in expression based on sex.
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