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September 23, 2026JAMA Psychiatry

Reducing Ultraprocessed Foods From the Diets of Patients With Depression

D. Nyasha Chagwedera Eliana Kim Dorothy T. Chiu Chengshi Jin Catherine Lee Susannah Tye Andrew Krystal

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Abstract

This pilot crossover trial assesses the feasibility and acceptability of removing ultraprocessed foods from the diets of patients with major depressive disorder.

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Cite This Study

Chagwedera et al. (2026) studied this question.

synapsesocial.com/papers/6ab60e74406bf401c1466ea7 https://doi.org/10.1001/jamapsychiatry.2026.2320

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Examining the effects of two dietary intervention approaches on disordered eating-related thoughts and behaviors in adults with moderate to moderately severe depressive symptomsRCT · 2026 · 1 citations
2Increasing Minimally Processed Food Intake in Depression via Commercial Meal Delivery: Qualitative Accounts of Participant ExperiencesRCT · 2026
3Meals that heal: a randomized controlled trial testing the feasibility of commercial meal delivery as a convenient dietary intervention for depressionRCT · 2026 · 2 citations
4UPDATE trial: investigating the effects of ultra-processed versus minimally processed diets following UK dietary guidance on health outcomes: a protocol for an 8-week community-based cross-over randomised controlled trial in people with overweight or obesity, followed by a 6-month behavioural intervention2024 · 13 citations
5Optimising Nutritional Psychiatry Treatment: Investigating the Mediterranean Diet to Improve Symptoms of Major Depressive Disorder (OPTIMISM): A double-blind sham-controlled randomised feeding trial protocolBlinded Clinical Trial · 2026

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Understanding the Variability of Associations Between Higher Ultra-Processed Food Consumption and Self-Reported Depression Severity: A Systematic Review of Epidemiological Studies2025
Poster Session I – A89 FOOD FOR MOOD: COMPARING THE EFFECTS OF THE MEDITERRANEAN DIET AND WESTERN DIET ON MENTAL HEALTH2026
Association between ultra-processed food intake, depression risk and quality of life in community-dwelling older adults2026

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