Interaction of the Anti-Cancer Drug Sulforaphane with DMPC Model Lipid Membranes

The interaction of the anti-cancer drug sulforaphane with DMPC lipid membranes was studied. Shift of the isothiocyanate vibrational band in the infrared spectra showed the incorporation of sulforaphane molecules into the lipid bilayer. At a lipid/sulforaphane ratio of 50/1, the internal radius and thickness of the lipid bilayer of unilamellar liposomes did not change significantly, as follows from the small-angle X-ray scattering data. An increase in the number of guest molecules (10/1) led to the fusion of liposomes and the formation of multilamellar vesicles.