What question did this study set out to answer?

Synthesize recent imaging literature evaluating how PET, MRI, and multimodal techniques characterize glial, metabolic, and neurovascular alterations across various neurodegenerative diseases.

September 25, 2026Discovery MedicineOpen Access

Neuroinflammation in Neurodegenerative Diseases: A Narrative Update (2020–2026) on Metabolic, Molecular, Morphological, and Functional Imaging

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Authors

ACAgostino ChiaravallotiUniversity of Rome Tor Vergata

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Implication

Narrative review reveals diverse imaging biomarkers of glial activation across neurodegenerative diseases, highlighting their utility for clinical trial stratification over routine diagnostics.

Key Points

Synthesize recent imaging literature evaluating how PET, MRI, and multimodal techniques characterize glial, metabolic, and neurovascular alterations across various neurodegenerative diseases.
Narrative review synthesizing original imaging publications indexed between January 1, 2020, and May 17, 2026.
Evaluated molecular and functional modalities, including translocator protein (TSPO) PET, MAO-B PET, FDG PET, diffusion MRI, quantitative susceptibility mapping, and blood-brain barrier imaging.
TSPO PET reliably tracks disease biology in Alzheimer's disease, correlating with amyloid-β deposition, tau burden, Braak-like spread, cognitive decline, and neural network dysfunction.
Evidence across frontotemporal dementia, progressive supranuclear palsy, Lewy body dementia, Parkinson's disease, and multiple system atrophy remains more limited and variable, supporting mechanistic phenotyping rather than standalone diagnosis.
Emerging targets and multimodal sequences provide stage-dependent and target-specific readouts suitable for clinical trial enrichment rather than routine clinical deployment.

Cite This Study

Agostino Chiaravalloti (2026) studied this question.

synapsesocial.com/papers/6ab60fbe406bf401c1468915 https://doi.org/10.24976/discov.med.202638212.210

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Implication

Narrative review reveals diverse imaging biomarkers of glial activation across neurodegenerative diseases, highlighting their utility for clinical trial stratification over routine diagnostics.

Neuroinflammation in Neurodegenerative Diseases: A Narrative Update (2020–2026) on Metabolic, Molecular, Morphological, and Functional Imaging

Discussion

Member takes

Implication

Key Points

Cite This Study

Neuroinflammation in Neurodegenerative Diseases: A Narrative Update (2020–2026) on Metabolic, Molecular, Morphological, and Functional Imaging

Discussion

Member takes

Implication

Key Points

Cite This Study

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