Key result
GLP-1 infusion increases heart rate and plasma insulin in calves, though less effectively than GRP.
Why the study?
The cardiovascular and pancreatic endocrine responses to GLP-1(7-36) amide in conscious calves given exogenous glucose were not fully characterized.
Does intravenous GLP-1 alter cardiovascular and pancreatic endocrine responses in conscious calves?
Population
Conscious calves given exogenous glucose (30-60 micromol min-1 kg-1 i.v.)
Comparison
Intravenous GLP-1(7-36) amide infusion vs baseline and vs gastrin-releasing peptide
Design
Preclinical experimental study
Follow-up
10 minutes
Authors
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Animal data on GLP-1 effects should not inform practice; leaves open translation to human cardiovascular responses.
Does intravenous GLP-1 alter cardiovascular and pancreatic endocrine responses in conscious calves?
In conscious calves, intravenous GLP-1 acutely increases heart rate and plasma insulin, though its insulinotropic effect is weaker than that of gastrin-releasing peptide.
EDWARDS et al. (1997) studied Conscious calves given exogenous glucose. Glucagon-like peptide-1(7-36) amide (GLP-1) was evaluated on Mean heart rate, mean aortic blood pressure, and plasma hormone concentrations. Intravenous infusion of GLP-1 in conscious calves produced a significant rise in mean heart rate and mean arterial plasma insulin, though it was less effective than GRP for insulin release.
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