Key result
Administration of flumazenil was associated with the development of generalized ballism in a single patient.
Case Report (n=1)
Flumazenil administration may induce generalized ballism, possibly through GABA-benzodiazepine receptor antagonism and dopamine hypersensitivity.
May prompt vigilance for rare movement disorders after flumazenil; leaves open mechanism and incidence.
Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is unknown. It is conceivable that flumazenil may antagonize the GABA-benzodiazepine receptor complex and induce dopamine hypersensitivity, thus induce dyskinesic symptoms.
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Kim et al. (2003) conducted a case report in Benzodiazepine reversal (n=1). Flumazenil was evaluated on Generalized ballism. Administration of flumazenil was associated with the development of generalized ballism in a single patient.
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