Key result
Blood cardioplegia reperfusion prevents LV mass gain and preserves compliance vs. beating-heart reperfusion.
Why the study?
The effects of reperfusion on global ventricular function, mass, and compliance during acute coronary occlusion and following reperfusion remain unclear, with conflicting reports on contractility and compliance recovery.
Does reperfusion with blood cardioplegia in the arrested heart prevent impairment of LV mass and compliance compared to reperfusion in the beating heart in a canine model of acute coronary occlusion?
Population
17 dogs on cardiopulmonary bypass with 45-minute proximal left anterior descending coronary artery occlusion
Comparison
Reperfusion in beating heart vs reperfusion with blood potassium cardioplegia in arrested heart
Design
Preclinical experimental study
Authors
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May favor arrested-heart cardioplegia reperfusion to preserve LV compliance; leaves open prospective clinical validation.
Does reperfusion with blood cardioplegia in the arrested heart prevent impairment of LV mass and compliance compared to reperfusion in the beating heart in a canine model of acute coronary occlusion?
In a canine model, reperfusion with blood cardioplegia in the arrested heart prevents the increase in LV mass and decrease in compliance seen with reperfusion in the beating heart.
Lazar et al. (1987) studied Acute coronary occlusion (n=17). Blood cardioplegia-based reperfusion in the arrested heart vs. Reperfusion in the beating heart was evaluated on Changes in left ventricular mass and compliance. Blood cardioplegia-based reperfusion in the arrested heart prevented the significant increase in LV mass and decrease in LV compliance (p<0.05) caused by reperfusion in the beating heart.