Key result
A serum superoxide dismutase cut-off of 0.52 U/mL predicted fetal death in severe preeclampsia and eclampsia with 68.5% sensitivity, 59.5% specificity, and 78.6% negative predictive value.
Why the study?
Does serum superoxide dismutase level predict fetal death and fulminating eclampsia in women with preeclampsia and eclampsia?
Observational
Does serum superoxide dismutase level predict fetal death and fulminating eclampsia in women with preeclampsia and eclampsia?
Serum superoxide dismutase levels <0.52 U/mL may serve as a predictive biomarker for fetal death and fulminating eclampsia in women with severe preeclampsia.
Answers are grounded in this paper and cite their sources.
May support fetal risk stratification in severe preeclampsia; hypothesis-generating and requires prospective validation before clinical use.
AIM: To report serum levels of superoxide dismutase in women with preeclampsia and eclampsia. To document the use of the value as a predictive tool for deciding the time of onset of subsequent convulsions with fulminating eclampsia and use of the value as a marker for obstetric intervention in clinical severe preeclampsia and eclampsia. METHODS: Superoxide dismutase concentration was measured in a consecutive study in sera of women admitted in obstetric ward for preeclampsia and eclampsia, and compared with sera of normotensive, healthy pregnant women in third trimester. Three mL venous blood was subjected to superoxide dismutase estimation by pyrogallol autoxidation method. RESULTS: We found statistically significant difference (P < 0.05) in mean superoxide dismutase levels of normotensive pregnant women; and preeclamptic and eclamptic subjects, no statistically significant difference was found in between value of enzyme in preeclampsia and eclampsia (P > 0.05). Superoxide dismutase levels in two pregnancy outcomes; live births and still births, shows significant difference (P < 0.05), being 1.03 U/mL and 0.52 U/mL, respectively. The comparison of values before delivery and after delivery showed highly statistically significant difference (P < 0.001) in both groups separately. The cut-off value of serum superoxide dismutase 0.52 U/mL has sensitivity 68.5%, specificity 59.5% and negative predictive value of 78.6%, for predicting the fetal death as outcome of pregnancy with severe grade of disease. CONCLUSION: We found low levels of serum superoxide dismutase, less than 0.52 U/mL, being the predecessor of fulminating eclampsia. Our results support this predictive value of serum superoxide dismutase level as important in deciding the time of intervention as termination of pregnancy.
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Mahadik et al. (2003) conducted an observational in Preeclampsia and eclampsia. Serum superoxide dismutase levels vs. Normotensive healthy pregnant women was evaluated on Fetal death (p=<0.05). A serum superoxide dismutase cut-off of 0.52 U/mL predicted fetal death in severe preeclampsia and eclampsia with 68.5% sensitivity, 59.5% specificity, and 78.6% negative predictive value.
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