Key result
Malignant pelvic paraganglioma presents as heart failure in a 35-year-old with rapid fatal course.
Why the study?
Neuroendocrine-related tumors such as paragangliomas can present with heart failure in young patients, but this association is not well recognized.
Case Report (n=1)
No
Neuroendocrine-related tumors such as paragangliomas should be considered in the differential diagnosis of young patients presenting with heart failure.
Paragangliomas merit consideration in young-onset heart failure; this case extends the differential but remains hypothesis-generating.
BACKGROUND: We present a case of pelvic paraganglioma that presented with heart failure as the primary symptom. CASE PRESENTATION: A 35-year-old man was admitted to hospital due to heart failure. Contrast-enhanced pelvic CT showed mass shadows in the posterior wall of the bladder and multiple enlarged lymph nodes in the retroperitoneal area. Ultrasound-guided puncture was performed, and the pathologic diagnosis was extra-adrenal paraganglioma. The patient refused any chemotherapy and died within six months of diagnosis. CONCLUSION: The possibility of neuroendocrine-related tumors, for example paragangliomas, should be considered in young patients with heart failure, especially those with concomitant hypertension and diabetes.
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Zhang et al. (2022) conducted a case report in Extra-adrenal paraganglioma presenting with heart failure (n=1). Extra-adrenal paraganglioma was evaluated. A 35-year-old man presenting with heart failure was diagnosed with a malignant extra-adrenal pelvic paraganglioma and died within six months after refusing chemotherapy.
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