The promise and potential hazards of adenovirus gene therapy

Importance The 2017 Clinical Practice Guideline (CPG) has categorized a greater proportion of children with elevated blood pressure (BP) or pHTN, and yet several barriers to CPG adherence have been noted. Objective To assess adherence to the 2017 CPG for the diagnosis and management of pHTN. Design Cross-sectional study using electronic health record-extracted data (January 1, 2018 to December 31, 2020). Setting AllianceChicago, a national Health Center Controlled Network of federally qualified health centers. Participants Children and adolescents (ages ≥3 and <18) who attended ≥1 visit and had ≥1 BP reading ≥90th percentile or diagnosis of elevated BP or pHTN. Exposure BP ≥90th percentile or ≥95th percentile. Main Outcomes and Measures 1) diagnosis of pHTN or elevated BP, 2) BP management (antihypertensive medication, lifestyle counseling, referral), and 3) follow-up visit attendance. Descriptive statistics described the sample and rates of guideline adherence. Logistic regression analyses identified patient-and clinic-level predictors of primary outcomes. Results Guideline-adherent diagnosis was observed in 8,811/23,334 (37.8%) children with BP ≥90th percentile, 6,427/15,423 (41.6%) children with BP ≥95th percentile, and 146/2,542 (5.7%) children with ≥3 visits with BP ≥95th percentile. A clinical decision support tool was used to calculate BP percentiles in 45.1% of cases and was associated with significantly greater odds of pHTN diagnosis (OR: 6.18, 95%CI: 5.06, 9.40). Among children with BP ≥95th percentile, antihypertensive medication was prescribed to 795/15,422 (5.2%) children, lifestyle counseling was provided to 14,841/15,422 (96.2%), and a BP-related referral was given to 848/15,422 (5.5%). Children seen at clinics in rural versus urban settings were more likely to be prescribed antihypertensive medication (OR: 1.96, 95%CI: 1.59, 2.41) and less likely to be given a BP-related referral (OR: 0.01, 95%CI: 0.00, 0.06). Guideline-adherent follow-up was observed in 8,651/19,049 (45.4%) children with BP ≥90th percentile and 2,598/15,164 (17.1%) children with BP ≥95th percentile. Conclusions and Relevance Fewer than 50% of children with elevated BP had a guideline-adherent diagnosis code or attended guideline-adherent follow-up. Using the clinical decision support tool increased guideline-adherent diagnosis, but was underutilized. Further work is needed to understand how to best support implementation of tools promoting pHTN diagnosis, management, and follow-up. Key points Question To what extent are clinicians adhering to the 2017 Clinical Practice Guideline for pediatric hypertension diagnosis, management, and follow-up? Findings In this cross-sectional study of 23,334 children (3-17 years old) with elevated blood pressure, less than half of children had a corresponding diagnosis in their medical chart or attended the recommended follow-up visit. A clinical decision support tool that aided in classifying blood pressure values increased rates of diagnosis, but was underutilized. Meaning Findings suggest that pediatric hypertension and elevated blood pressure remain underdiagnosed and undertreated among high-risk children, which portends negative health consequences in adulthood.