Key result
Reduced glutathione increases abnormal CK-MM sub-bands, an effect reversed by oxidized glutathione.
Why the study?
The effects of glutathione on the sub-bands of serum creatine kinase isoenzyme MM in acute myocardial infarction were not fully understood.
Population
Serum samples from patients with acute myocardial infarction and myocardium tissue extract
Comparison
Incubation with reduced glutathione (GSH) vs oxidized glutathione (GSSG)
Design
Isoelectric focusing study in polyacrylamide gels
Authors
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May artifactually alter CK-MM sub-bands via redox state; leaves open relevance to clinical isoform testing.
Glutathione mediates the interconversion of 'normal' and 'abnormal' sub-bands of creatine kinase isoenzyme MM, which may impact the biochemical diagnosis of myocardial infarction.
Williams et al. (1990) studied Acute myocardial infarction. Glutathione (reduced and oxidized) was evaluated on Changes in intensity of abnormal and normal sub-bands of CK-MM. Incubation of serum with reduced glutathione increased the intensity of abnormal CK-MM sub-bands and decreased normal sub-bands, a process reversed by oxidized glutathione.
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