Key result
HLA B7 peptide triggers cytotoxic CD8 T cell responses in anti-Hu syndrome.
Why the study?
Half of patients with limbic encephalitis and small cell lung carcinoma have anti-Hu antibodies reacting with neuronal nuclei, but the role of peptides binding HLA B7 supertype in CD8-positive T cell response is unclear.
Observational (n=7)
May support anti-Hu testing in SCLC-associated limbic encephalitis; leaves open diagnostic utility without prospective validation.
Half of the patients with limbic encephalitis and small cell lung carcinoma have an anti-Hu antibody that reacts with all central and peripheral nervous system neuronal nuclei in immunohistochemical studies, as well as 35 to 40 l
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Tanaka et al. (2000) conducted an observational in Anti-Hu syndrome (n=7). HLA B7 supertype was evaluated on Presence of HLA B7 supertype and CD8-positive cytotoxic T cell activity. Seven patients with anti-Hu syndrome demonstrated the presence of the HLA B7 supertype and CD8-positive cytotoxic T cell activity reacting with a peptide containing HLA B7 binding motifs.
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