Key result
Intermittent hypobaric hypoxia increases erythropoiesis and induces marked right ventricular hypertrophy.
Why the study?
The effects of simulated high altitude on erythropoiesis and right ventricular hypertrophy in meat-type chickens were not well characterized.
Does intermittent hypobaric hypoxia induce erythropoiesis and right ventricular hypertrophy in broiler chickens?
Population
Broiler chickens (meat-type)
Comparison
Simulated high altitude (2054 m) intermittent hypoxia vs atmospheric pressure (295 m)
Design
Preclinical experimental study with hypobaric chamber exposure
Follow-up
2, 4, 8, or 16 hours per day exposure periods
Authors
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Establishes broiler model of hypoxia-induced polycythemia and RV hypertrophy; hypothesis-generating for mammalian pulmonary vascular research.
Does intermittent hypobaric hypoxia induce erythropoiesis and right ventricular hypertrophy in broiler chickens?
Intermittent hypoxia of 8 or more hours per day induces significant polycythemia and right ventricular hypertrophy in broiler chickens.
Julian et al. (1994) studied this question. Intermittent hypobaric hypoxia (simulated high altitude of 2054 m) vs. Atmospheric pressure (altitude 295 m) was evaluated on Erythropoiesis (haematocrit and haemoglobin levels) and right ventricular hypertrophy. Intermittent hypobaric hypoxia of 8 or 16 hours per day produced significantly higher haematocrit and haemoglobin levels than controls, alongside moderate to marked right ventricular hypertrophy.
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