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June 1, 1989American Review of Respiratory Disease

The Relationship between Rapid Growth and Pulmonary Hemodynamics in the Fast-growing Broiler Chicken

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Why the study?

Does rapid growth amplify hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in broiler chickens?

Population

28 awake very fast-growing (VFG) chickens, normal chickens, and 2-wk-old normal and VFG chicks

Comparison

Hypoxic stimulus and diet restriction vs Normal chickens, room air, and unrestricted diet

Design

Preclinical

Follow-up

2 weeks

Authors

APAndrew J. PeacockGolden Jubilee National HospitalKMKen MorrisBoeing (United States)JRJohn Τ. ReevesRegeneron (United States)

Discussion

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Implication

Rapid growth amplifies hypoxia-induced pulmonary hypertension in broilers; leaves open translational relevance to human right ventricular disease.

Structured PICO

Does rapid growth amplify hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in broiler chickens?

P
Population
28 awake very fast-growing (VFG) chickens, normal chickens, and 2-wk-old normal and VFG chicks
I
Intervention
Hypoxic stimulus (reduced FIO2 or hypobaric chamber at 10,000 feet for 2 weeks) and diet restriction
C
Comparator
Normal chickens, room air, and unrestricted diet
O
Outcome
Pulmonary artery pressure (Ppa), right ventricular hypertrophy (RVH), and total pulmonary resistance (TPR)surrogate

Rapid growth acts as an important amplifier of hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in an animal model.

Cite This Study

Peacock et al. (1989) studied this question.

synapsesocial.com/papers/6a8914fcb77be3c6541309b2https://doi.org/10.1164/ajrccm/139.6.1524
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic Study of Pulmonary Hypertension Syndrome in Broiler Chickens2000 · 7 citations
  2. 2Haematopoietic and right ventricular response to intermittent hypobaric hypoxia in meat‐type chickens1994 · 9 citations
  3. 3Blood Oxygen Concentration of Fast-Growing and Slow-Growing Broiler Chickens, and Chickens with Ascites from Right Ventricular Failure1992 · 95 citations
  4. 4Transpulmonary Pressure Gradient Verifies Pulmonary Hypertension is Initiated by Increased Arterial Resistance in Broilers2007 · 22 citations
  5. 5The Relationship of Right Ventricular Hypertrophy, Right Ventricular Failure, and Ascites to Weight Gain in Broiler and Roaster Chickens1987 · 130 citations