Key result
RAC1 rs6967221 T allele is linked to a ~4.5 mmHg lower systolic response to dietary sodium.
Why the study?
The associations of genetic variants of NADPH oxidase-related genes with blood pressure responses to dietary sodium intervention in a Chinese population were not comprehensively tested.
Do genetic variants of NADPH oxidase-related genes affect blood pressure responses to dietary sodium intervention in a Chinese population?
Cohort (n=1,906)
Do genetic variants of NADPH oxidase-related genes affect blood pressure responses to dietary sodium intervention in a Chinese population?
Genetic variants in NADPH oxidase-related genes, particularly RAC1, are associated with blood pressure responses to dietary sodium interventions in a Chinese population.
BACKGROUND: The aim of this study was to comprehensively test the associations of genetic variants of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-related genes with blood pressure (BP) responses to dietary sodium intervention in a Chinese population. METHODS: We conducted a 7-day low-sodium intervention followed by a 7-day high-sodium intervention among 1,906 participants in rural China. BP measurements were obtained at baseline and each dietary intervention using a random-zero sphygmomanometer. Linear mixed-effect models were used to assess the additive associations of 63 tag single-nucleotide polymorphisms in 11 NADPH oxidase-related genes with BP responses to dietary sodium intervention. Gene-based analyses were conducted using the truncated product method. The Bonferroni method was used to adjust for multiple testing in all analyses. RESULTS: Systolic BP (SBP) response to high-sodium intervention significantly decreased with the number of minor T allele of marker rs6967221 in RAC1 (P = 4.51 × 10-4). SBP responses (95% confidence interval) for genotypes CC, CT, and TT were 5.03 (4.71, 5.36), 4.20 (3.54, 4.85), and 0.56 (-1.08, 2.20) mm Hg, respectively, during the high-sodium intervention. Gene-based analyses revealed that RAC1 was significantly associated with SBP response to high-sodium intervention (P = 1.00 × 10-6) and diastolic BP response to low-sodium intervention (P = 9.80 × 10-4). CONCLUSIONS: These findings suggested that genetic variants of NADPH oxidase-related genes may contribute to the variation of BP responses to sodium intervention in Chinese population. Further replication of these findings is warranted.
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Han et al. (2017) conducted a cohort in Blood pressure response to dietary sodium (n=1,906). Genetic variants of NADPH oxidase-related genes (e.g., RAC1) vs. Reference genotypes was evaluated on Systolic blood pressure response to high-sodium intervention (p=4.51 × 10-4). The minor T allele of RAC1 rs6967221 was significantly associated with a decreased systolic blood pressure response to high-sodium intervention (SBP responses for CC, CT, and TT were 5.03, 4.20, and 0.56 mm Hg; P=4.51×10-4).
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