Key result
The AA genotype of the A1789G polymorphism in the hKLK1 gene showed a marginal association with hypertension in a Korean population (P=0.0754).
Why the study?
The genetic influence of kallikrein-kinin system components on hypertension susceptibility in Koreans was unclear.
Do genetic polymorphisms in the kallikrein-kinin system associate with hypertension in Koreans?
Case-Control
Do genetic polymorphisms in the kallikrein-kinin system associate with hypertension in Koreans?
p-value: p=0.0754
The A1789G polymorphism in the hKLK1 gene may weakly contribute to hypertension susceptibility in the Korean population.
Hypothesis-generating marginal association in Koreans; prospective studies needed before any clinical consideration.
The kallikrein‐kinin system affects regulation of blood pressure, and genes encoding for the components of this system have been considered as good candidates for hypertension. To evaluate the relationship between genetic polymorphisms of candidate genes involved in this system and hypertension, we performed case‐control studies using genetic markers in Korean normotensives and hypertensives, respectively. By association study, there was a marginal association with hypertension in AA genotype distribution of A1789G polymorphism in the hKLK1 gene (P=0.0754). Thus, this genetic polymorphism may weakly contribute to the susceptibility to hypertension in Koreans. We also observed that significant linkage disequilibrium exists among three polymorphic sites in the hKLK1 gene studied, suggesting that the three genetic polymorphisms can be useful as genetic markers in clinical association studies. Further studies using larger sample sizes and more genetic markers will be needed to clarify genetic influence of kallikrein‐kinin system for hypertension.
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Kang et al. (2004) conducted a case-control in Hypertension. A1789G polymorphism in the hKLK1 gene vs. Normotensives was evaluated on Hypertension (p=0.0754). The AA genotype of the A1789G polymorphism in the hKLK1 gene showed a marginal association with hypertension in a Korean population (P=0.0754).
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