Large squamous cell carcinoma of the lip in a Black woman with a history of hydrochlorothiazide use treated with Mohs micrographic surgery

Squamous cell carcinoma (SCC) of the lip comprises 25% to 30% of all oral cancers, with an estimated incidence of 0.4 in 100,000 per year.1 Multiple studies have demonstrated that SCC is the most common type of nonmelanoma skin cancer (NMSC) to affect the vermilion lip, although some studies have suggested that basal cell carcinoma is more common.1-5 However, it is widely accepted that SCC occurs more commonly on the lower vermilion lip, accounting for ∼80% of NMSC cases in this region.2,4 Consent was provided by the patient for publication of case details and images.