Key result
Long-term cohort follow-up shows continuous declines in MI incidence alongside delayed reductions in stroke.
Why the study?
Changes in the incidence of fatal and nonfatal myocardial infarction and stroke over two decades in the same male population were not well characterized.
Cohort (n=16,209)
The incidence of fatal and nonfatal MI and stroke declined significantly over a 21-year period in a cohort of middle-aged Norwegian men.
Incidence trends in middle-aged Oslo men warrant monitoring; leaves open whether patterns apply to women, other regions, or post-1990s cohorts.
OBJECTIVES: To explore changes in the incidence of fatal and nonfatal myocardial infarction (MI) and stroke in the same male population over two decades. DESIGN: Men aged 40-49 born in the years 1923-1932 (N= 16,209) resident in Oslo participated in a cardiovascular screening programme in 1972-1973. Nonfatal cases of MI and stroke were obtained from hospital records and causes of death were ascertained by linkage to Statistics Norway. The closing date was December 31, 1993. RESULTS: The cohort had a lower mortality rate than the general Norwegian population. First nonfatal and fatal MIs declined in each age and birth cohort during the entire follow-up. The incidence of nonfatal and fatal stroke decreased about 10 years after the initial screening. The risk of men with Rose questionnaire-based symptoms of angina or claudication was between that of healthy men and men with established cardiovascular disease or diabetes. CONCLUSIONS: There has been a reduction in both nonfatal and fatal incident cases of MI and stroke 10 years later indicating a pronounced change in all age groups and a lasting change throughout the period of follow-up. The Rose questionnaire predicted both future stroke and MI.
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Håheim et al. (2004) conducted a cohort in Myocardial infarction and stroke (n=16,209). Time (calendar year) was evaluated on Incidence of fatal and nonfatal myocardial infarction (MI) and stroke. A 21-year follow-up of 16,209 men showed a continuous decline in first nonfatal and fatal myocardial infarctions across all cohorts, with stroke incidence decreasing after 10 years.
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