Veto Function in Vitro and in Vivo

A CTLp recognizing another cell, called veto cell, is suppressed by that veto cell. The veto cell can itself be a CTL. For the veto function, the TCR of the veto cell is not required, hence the veto function is a backward action of CTL. Since, from the point of view of the veto cell, only self-reactive CTLp are suppressed, the veto function could be a mechanism for maintaining self tolerance of CTL. The characteristics of veto function in vitro and in vivo are discussed, as well as the potential physiological relevance.