Key result
Virions derived from biologically active chimeric DNA clones with one or two NF-kB sites did not induce the acute death syndrome characteristic of PBj infection.
Population
Tissues of an infected macaque (SIVsmm/PBj)
Design
Preclinical
Authors
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NF-kB duplication alone insufficient for PBj acute syndrome; leaves open its interaction with other SIV determinants in pathogenesis.
The duplicated NF-kB site in SIVsmm/PBj either acts in concert with other viral determinants or plays no role in producing the PBj acute death syndrome.
Novembre et al. (1991) studied SIVsmm/PBj infection (n=1). Biologically active chimeric DNA clones with one or two NF-kB sites was evaluated on Induction of acute death syndrome. Virions derived from biologically active chimeric DNA clones with one or two NF-kB sites did not induce the acute death syndrome characteristic of PBj infection.
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