Hyperintentionality Hypothesis of Major Depression. Disordered Emotional and Cognitive Self-Observation in Tripartite Synapses and the Glial Networks

Major depressive disorder is basically a disorder of the integration of distinct time periods generated in tripartite synapses and the astroglial networks. If the sequence of time periods is dysregulated, the patient does not only suffer from emotional impairment but also from cognitive deficits dependent on the brain region affected. Since the synaptic interactions operate on feedforward and feedback mechanisms, I speak of synaptic locations of self-observation in real time periods, information processing time periods and information integration time periods. If connexins in the astroglial network are overexpressed, the number of astrocytic receptors in tripartite synapses is also overexpressed.