Key result
C5b-9 reliably detects early myocardial ischemia post mortem before standard histological changes appear.
Why the study?
The role and diagnostic utility of complement components and membrane attack complex (MAC) in post mortem myocardial ischemia/infarction require systematic evaluation.
Does the membrane attack complex (MAC) serve as a reliable marker for the post mortem diagnosis of myocardial ischemia/infarction?
Population
26 studies evaluating post mortem myocardial ischemia/infarction
Comparison
Evaluation of complement components and MAC C5b-9
Design
Systematic literature review
Authors
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Supports C5b-9 immunostaining in forensic autopsies for suspected early myocardial ischemia; extends immunohistochemical evidence via systematic synthesis.
Systematic Review (n=26)
Does the membrane attack complex (MAC) serve as a reliable marker for the post mortem diagnosis of myocardial ischemia/infarction?
The membrane attack complex (MAC) is a useful and stable post mortem marker for diagnosing myocardial ischemia and infarction.
Mondello et al. (2020) conducted a systematic review in Myocardial ischemia/infarction (post mortem diagnosis) (n=26). Membrane Attack Complex (MAC/C5b-9) analysis vs. Routine histological analysis or non-ischemic controls was evaluated on Post mortem diagnosis of early myocardial ischemia/infarction. The membrane attack complex (C5b-9) is a sensitive, specific, and stable post mortem marker for the early diagnosis of myocardial ischemia, detectable before routine histological signs appear.
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