Key result
Co-administration of morin with cyclophosphamide in rats fully restored hepatic glutathione levels (98.33 vs 88.85 μM, p<0.005) but did not reverse the decrease in superoxide dismutase activity.
Absolute Event Rate: 98.33% vs 88.85%
p-value: p=<0.005
Morin may exert protective effects against cyclophosphamide-induced oxidative stress in the liver by restoring glutathione levels.
Morin partially restored GSH but not SOD in CPX-treated rat livers; hypothesis-generating for hepatoprotection, with no implications for clinical use.
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Merwid‐Ląd et al. (2014) studied Cyclophosphamide-induced oxidative stress (n=36). Morin vs. Cyclophosphamide alone (15 mg/kg) was evaluated on Glutathione (GSH) concentration in liver tissue homogenates (μM) (p=<0.005). Co-administration of morin with cyclophosphamide in rats fully restored hepatic glutathione levels (98.33 vs 88.85 μM, p<0.005) but did not reverse the decrease in superoxide dismutase activity.
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