Key result
Oral administration of morin (especially at 50 mg/kg bw) normalized blood pressure, hepatic enzymes, and renal function markers in DOCA-salt hypertensive rats.
Why the study?
Does oral morin reduce blood pressure and improve hepatic and renal markers in male Wistar rats with DOCA-salt induced hypertension?
Does oral morin reduce blood pressure and improve hepatic and renal markers in male Wistar rats with DOCA-salt induced hypertension?
Morin exhibits a strong, dose-dependent antihypertensive and organ-protective effect in a rat model of DOCA-salt induced hypertension, with optimal efficacy at 50 mg/kg.
Should not change clinical practice; hypothesis-generating for morin in salt-sensitive hypertension models.
OBJECTIVE: To determine the protective effect of morin, a flavonoid against deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats. METHODS: Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA (25 mg/kg bw) and 1% NaCl in the drinking water for six consecutive weeks. Effect of morin against DOCA-salt induced hypertension was evaluated by measuring blood pressure and performing biochemical estimations and histopathological examination of renal tissues. RESULTS: DOCA-salt hypertensive rats showed considerably increased systolic and diastolic blood pressure, serum hepatic marker enzyme activities such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT) and renal function markers (urea, uric acid and creatinine) in plasma. Oral administration of morin (25, 50 and 75 mg/kg bw) brought back all the above parameters to near normal level. Histopathology of kidney also confirmed the biochemical findings of this study. The effect at a dose of 50 mg/kg bw of morin was more pronounced than that of the other two doses (25 and 75 mg/kg bw). CONCLUSIONS: These findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension.
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Kumar et al. (2012) studied DOCA-salt induced hypertension. Morin vs. Untreated DOCA-salt hypertensive rats was evaluated on Blood pressure, serum hepatic marker enzyme activities, and renal function markers. Oral administration of morin (especially at 50 mg/kg bw) normalized blood pressure, hepatic enzymes, and renal function markers in DOCA-salt hypertensive rats.
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