Key result
Ionized magnesium-guided high-dose magnesium sulfate terminates refractory drug-induced torsades de pointes.
Why the study?
Total magnesium concentration is not correlated with ionized magnesium concentration, especially in severely ill patients, complicating treatment of refractory torsades de pointes due to drug-induced long QT syndrome.
Population
One woman in her 60s with refractory TdP due to drug-induced long QT syndrome after thoracic compression fracture surgery
Comparison
High-dose magnesium sulfate guided by point-of-care ionized magnesium monitoring
Design
Case report
Follow-up
11 days
Authors
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iMg-guided magnesium dosing resolved refractory TdP in this case; hypothesis-generating observation requiring prospective validation.
Case Report (n=1)
No
Point-of-care monitoring of ionized magnesium may be effective for guiding high-dose magnesium sulfate therapy in refractory drug-induced torsades de pointes.
Matsuura et al. (2021) conducted a case report in Refractory Torsades de Pointes due to drug-induced long QT syndrome (n=1). Magnesium sulfate guided by ionized magnesium monitoring was evaluated on Termination of Torsades de Pointes. Refractory torsades de pointes due to drug-induced long QT syndrome was successfully terminated by administering high-dose magnesium sulfate guided by point-of-care monitoring of ionized magnesium.
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