Key result
In hospitalized patients with chronic kidney disease, 58.2% of drugs requiring dose adjustment were unadjusted, and Stage 5 CKD was significantly associated with medication dosing errors (OR 0.098) compared to Stage 3.
Population
205 CKD patients with eGFR ≤60ml/min/1.73m2, hospitalized ≥24 hours in a nephrology unit, mean age 38.64…
Design
Cohort
Authors
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High dosing error rates in hospitalized CKD patients warrant clinical vigilance; observational data leaves open whether interventions reduce harm.
Observational (n=205)
No
Odds Ratio: 0.098 (95% CI 0.04–0.241)
Absolute Event Rate: 86.5% vs 26.3%
p-value: p=<0.001
More than half of the medications requiring dose adjustment in hospitalized CKD patients were unadjusted, with higher risk in severe CKD, polypharmacy, and hypertension.
Saleem et al. (2016) conducted an observational in Chronic Kidney Disease (CKD) (n=205). Stage 5 Chronic Kidney Disease vs. Stage 3 Chronic Kidney Disease was evaluated on Medication dosing errors (unadjusted drugs) (OR 0.098, 95% CI 0.040-0.241, p=<0.001). In hospitalized patients with chronic kidney disease, 58.2% of drugs requiring dose adjustment were unadjusted, and Stage 5 CKD was significantly associated with medication dosing errors (OR 0.098) compared to Stage 3.
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