Key result
Specific VDR gene variants are linked to arterial hypertension and altered renin levels in obese patients.
Why the study?
The characteristics of the renin-angiotensin-aldosterone system in patients with polymorphic variants of the VDR gene, arterial hypertension, and obesity were not well studied.
Are polymorphic variants of the VDR gene associated with arterial hypertension and altered RAAS markers in obese patients?
Cross-Sectional (n=98)
Are polymorphic variants of the VDR gene associated with arterial hypertension and altered RAAS markers in obese patients?
Polymorphic alleles and genotypes of the VDR gene (BsmI and FokI) are associated with arterial hypertension and altered renin levels in obese patients, suggesting a potential genetic predictor for hypertension development.
Supports VDR variant associations with hypertension in obesity; leaves open predictive utility pending prospective validation.
AIM: to study the renin-angiotensin-aldosterone-system (RAAS) in patients with polymorphic variants of the vitamin D receptor gene (VDR), arterial hypertension (AH) and obesity. MATERIALS AND METHODS: We included in this study 98 patients with stage II-III AH and obesity (33 men, 65 women, mean age 61.1±9.9 years and BMI 43.3±5.0 kg/m2). The VDR gene study included genotypes TaqI, BsmI, FokI. After identification of TaqI, BsmI, FokI VDR gene sites we carried out measurements of levels of RAAS markers. RESULTS: We revealed an associative relationship between the presence of allele G of the BsmI site, C/C homozygosity of FokI site of VDR gene and presence of AH in patients with obesity. An increase of renin level was noted only in the homozygous T/T genotype of FokI, no differences in the concentration of aldosterone and angiotensin were detected between any of the studied genotypes. CONCLUSION: Polymorphic alleles and genotypes of the VDR gene can be used as predictors of AH development in obese patients with subsequent characterization of the state of the RAAS system.
No takes yet. Share an insight, caveat, or question.
Сенцова et al. (2018) conducted a cross-sectional in Arterial hypertension and obesity (n=98). Polymorphic variants of the VDR gene (TaqI, BsmI, FokI) vs. Other genotypes/alleles was evaluated on Levels of RAAS markers (renin, aldosterone, angiotensin) and presence of arterial hypertension. Allele G of the BsmI site and C/C homozygosity of the FokI site of the VDR gene were associated with arterial hypertension in obese patients, with increased renin noted in the T/T FokI genotype.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: