Key result
Untreated hypertension is linked to ~12% lower left atrial peak positive strain vs. healthy controls.
Why the study?
Changes in the three phases of left atrial function have not been well studied in hypertension.
Does untreated hypertension alter left atrial phasic function assessed by speckle tracking echocardiography compared to healthy controls?
Observational (n=93)
Does untreated hypertension alter left atrial phasic function assessed by speckle tracking echocardiography compared to healthy controls?
Absolute Event Rate: 39.8% vs 45.3%
p-value: p=0.031
Untreated hypertension is associated with decreased left atrial phasic function, and reduced LA conduit function is independently associated with diastolic dysfunction.
Untreated hypertension linked to reduced LA phasic strain; hypothesis-generating for speckle tracking in diastolic assessment.
Changes in the three phases of left atrial (LA) function have not been well studied in hypertension. We studied phasic function of LA by speckle tracking echocardiography (STE) in hypertension. Sixty-one consecutive untreated hypertension patients and 32 sex- and age-matched healthy participants were included. Two-dimensional (2D) images obtained from apical four-chamber and two-chamber views were used for STE analysis of LA. LA peak positive strain (39.8 ± 10.9 vs. 45.3 ± 12.7 %, p = 0.031), peak negative strain (−2.2 ± 1.5 vs. −3.0 ± 1.9 %, p = 0.029), and conduit strain rate (−2.0 ± 0.5 vs. −2.4 ± 0.6 1/s, p = 0.005) were significantly decreased in hypertension. Twenty hypertensive patients (32%) had diastolic dysfunction. Positive strain (34.8 ± 7.2 vs. 42.2 ± 11.6 %, p = 0.012) and conduit strain rate (−1.7 ± 0.4 vs. −2.2 ± 0.5 1/s, p < 0.001) were decreased in patients with diastolic dysfunction. Only conduit strain rate was independently associated with diastolic dysfunction (OR 11.9, p = 0.026) after multivariable analysis. LA phasic function is decreased in untreated hypertension. Decreased LA conduit function is associated with diastolic dysfunction in hypertension.
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Tsai et al. (2012) conducted an observational in Untreated hypertension (n=93). Untreated hypertension vs. Healthy participants was evaluated on Left atrial peak positive strain (p=0.031). Untreated hypertension was associated with significantly decreased left atrial peak positive strain (39.8% vs. 45.3%, p=0.031) compared to healthy matched controls.
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