Key result
Remimazolam provides superior hemodynamic stability over midazolam in severe aortic stenosis during interventional radiology.
Why the study?
Patients with aortic stenosis and significant cardiopulmonary comorbidities are vulnerable to hemodynamic instability during anesthesia, and comparative data on sedative agents in this population are limited.
Does remimazolam improve hemodynamic stability compared to midazolam in a high-risk patient with aortic stenosis undergoing interventional radiology procedures?
Case Report (n=1)
Does remimazolam improve hemodynamic stability compared to midazolam in a high-risk patient with aortic stenosis undergoing interventional radiology procedures?
Remimazolam may offer a more stable hemodynamic profile than midazolam for moderate sedation in high-risk patients with aortic stenosis and cardiopulmonary comorbidities.
Patients with aortic stenosis (AS) and other significant cardiopulmonary comorbidities are vulnerable to hemodynamic instability during anesthesia. This case report compares the use of remimazolam and midazolam in a 71-year-old man with symptomatic AS, chronic kidney disease, and ischemic cardiomyopathy. The patient underwent multiple short ambulatory interventional radiology procedures. While moderate sedation with midazolam resulted in significant hypotension, use of remimazolam in subsequent procedures demonstrated a stable hemodynamic profile despite increased disease burden. This report highlights the potential advantages of remimazolam compared to midazolam in high-risk patients undergoing interventional radiology procedures.
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Serafin et al. (2024) conducted a case report in Aortic stenosis, chronic kidney disease, and ischemic cardiomyopathy (n=1). Remimazolam vs. Midazolam was evaluated on Hemodynamic stability. Remimazolam provided a stable hemodynamic profile compared to midazolam, which caused significant hypotension, in a high-risk patient with aortic stenosis undergoing interventional radiology procedures.
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