Key result
Central contrast injection nearly doubles peak arterial enhancement vs peripheral delivery for IV-DSA.
Why the study?
Controversy exists regarding the selection of a central versus peripheral injection site for intravenous digital subtraction angiography (IV-DSA).
Does central injection improve the peak and width of the arterial time-concentration curve compared to peripheral injection for IV-DSA in dogs?
Population
36 injections of contrast media in dogs
Comparison
Central injection sites (main pulmonary artery, subclavian vein) versus peripheral injection site (cephalic vein)
Design
Latin-square experimental design in vivo quantitative x-ray measurement study
Authors
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Central access may optimize IV-DSA contrast curves in dogs; leaves open translation to human angiography.
Does central injection improve the peak and width of the arterial time-concentration curve compared to peripheral injection for IV-DSA in dogs?
Central injection sites optimize IV-DSA examinations by providing greater peak enhancement and narrower time-concentration curves compared to peripheral injection.
Rubin et al. (1984) studied Intravenous digital subtraction angiography (IV-DSA). Central injection (pulmonary artery or subclavian vein) vs. Peripheral injection (cephalic vein) was evaluated on Peak and width of the arterial time-concentration curve. Central injection into the pulmonary artery or subclavian vein produced higher peak enhancement (100% and 93% vs 56%) and narrower curve widths than peripheral cephalic vein injection in dogs.
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