November 1, 1999Biological PsychiatryOpen Access

The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias

Q: What is the clinical evidence from this study?

Study design: Review. Population: Anxiety spectrum disorders (panic disorder, generalized anxiety disorder, phobias). Intervention: Noradrenergic system.

Q: What does this research mean for the field?

Abnormalities and dysregulation in the noradrenergic system play a central role in the pathophysiology of anxiety spectrum disorders, including panic disorder, generalized anxiety disorder, and phobias. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Review details central noradrenergic pathways in anxiety spectrum disorders and outlines emerging treatment targets.

Why the study?

Abnormalities in the noradrenergic system have been identified in anxiety disorders such as panic disorder, but current conceptualizations of pathophysiologies require elucidation.

Population

Patients with anxiety spectrum disorders including panic disorder, generalized anxiety disorder, and phobias

Design

Review article

Authors

GSGregory M. SullivanCyclacel Pharmaceuticals (United States)JCJeremy D. CoplanWinthrop-University Hospital JKJustine KentArtistic Realization Technologies

Discussion

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Implication

Synthesizes noradrenergic pathways in anxiety; leaves open targeted trials in cardiovascular patients with comorbid anxiety.

Structured PICO

Population

Patients with anxiety spectrum disorders such as panic disorder, generalized anxiety disorder, and phobias

This review summarizes the role of the noradrenergic system in the pathophysiology and treatment of anxiety spectrum disorders.

Cite This Study

Sullivan et al. (1999) conducted a review in Anxiety spectrum disorders (panic disorder, generalized anxiety disorder, phobias). Noradrenergic system was evaluated. This review delineates the central functions of the noradrenergic system in anxiety spectrum disorders, discussing relevant neuroanatomic pathways and implications for treatment.

synapsesocial.com/papers/6ab73fc6dcabe5d01d58fb25 https://doi.org/10.1016/s0006-3223(99)00246-2

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The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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