Key result
Prior MI linked to >2-fold higher right atrial appendage ENG and NPPB expression.
Why the study?
The expression levels of angiogenesis-related genes in patients with different types of heart failure and myocardial ischemia were not well characterized.
Cross-Sectional (n=3)
No
Necrosis accompanying myocardial infarction may be a significant factor leading to elevated expression levels of genes involved in neoangiogenesis in the right atrial appendage.
Answers are grounded in this paper and cite their sources.
ENG/NPPB expression differed by prior MI in atrial samples; hypothesis-generating for post-infarct neoangiogenesis, needs validation before any clinical consideration.
INTRODUCTION: The most frequent cause of myocardial ischemia is atherosclerotic lesions which narrow coronary vessels leading to impaired blood flow or their total occlusion. MATERIAL AND METHODS: Using HG-U133A oligonucleotide microarrays (Affymetrix) we studied the expression levels of angiogenesis-related genes in patients with different types of heart failure. We analyzed the RNA from right atrial appendages from patients: 1) with advanced coronary disease and myocardial infarction history, 2) with advanced stable coronary disease and no infarction history, and 3) after surgery due to mitral stenosis, but with no coronary vessel lesions. RESULTS: Analysis of the data from oligonucleotide microarrays allowed identification of 2 genes (ENG and NPPB) differentiating the examination grups. CONCLUSIONS: Analysis of the expression profile of genes involved in angiogenesis, carried out using data obtained from examined individuals' samples, suggests that necrosis accompanying myocardial infarction is a significant factor leading to elevated expression levels of genes involved in neoangiogenesis.
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Dąbek et al. (2013) conducted a cross-sectional in Advanced myocardial ischemia (n=3). History of myocardial infarction vs. No history of myocardial infarction was evaluated on Expression levels of ENG and NPPB genes (>2-fold higher). Expression levels of angiogenesis-related genes ENG and NPPB were more than two-fold higher in the right atrial appendage of a patient with a history of myocardial infarction compared to those without.
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