Key result
Influenza-associated encephalopathy was associated with greater up-regulation of IL-6, IL-10, and TNF-alpha gene transcription compared to influenza without neurologic complications.
Why the study?
Is influenza-associated encephalopathy associated with increased systemic cytokine responses compared to influenza without neurologic complications?
Population
Patients with influenza and encephalopathy or febrile convulsions, and patients with influenza but without…
Design
Cross-sectional
Authors
Loading...
Supports immune-mediated mechanism in influenza encephalopathy; hypothesis-generating and requires prospective validation before clinical consideration.
Observational
Is influenza-associated encephalopathy associated with increased systemic cytokine responses compared to influenza without neurologic complications?
Influenza-associated encephalopathy is associated with elevated systemic cytokine responses rather than increased viral load, suggesting an immune-mediated mechanism.
Kawada et al. (2003) conducted an observational in Influenza-associated encephalopathy. Influenza-associated encephalopathy vs. Influenza without neurologic complications was evaluated on Transcription of cytokine genes (IL-6, IL-10, TNF-alpha) and viral load. Influenza-associated encephalopathy was associated with greater up-regulation of IL-6, IL-10, and TNF-alpha gene transcription compared to influenza without neurologic complications.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: