Key result
Heparin rebound occurs in ~43% post-CPB but is linked to clinically unimportant bleeding.
Why the study?
The incidence and clinical impact of heparin-rebound after protamine neutralization following cardiopulmonary bypass were not well characterized.
Population
Patients undergoing cardiopulmonary bypass with systemic heparinization
Comparison
Heparin-effect presence versus absence after protamine neutralization
Design
Observational study
Follow-up
8 hours
Authors
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Does not support routine heparin-rebound testing or reversal post-CPB; leaves open its prognostic value in prospective cohorts.
Observational
Heparin-rebound is a common phenomenon in the first 8 hours following cardiopulmonary bypass and protamine reversal, though the associated increase in bleeding appears clinically insignificant.
Subramaniam et al. (1995) conducted an observational in Cardiopulmonary bypass. Heparin-rebound phenomenon was evaluated on Incidence of heparin-effect at 2, 4, and 8 hours. Heparin-rebound was detected in 43% of patients at 2 hours post-cardiopulmonary bypass and was associated with a small but clinically unimportant increase in postoperative bleeding.
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