Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration

Figures

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  Figure 1. Reconstruction stages of the vascular network geometry for one of the animals: (a) MRI data, (b) vector image.

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  Figure 2. Anatomy of the mice circle of Willis (CoW). (a): The arteries are common carotid artery (CCA), vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), middle cerebral artery (MCA), posterior communicating artery (PcoA) and anterior communicating artery (AcoA). – L denotes left side, and − R—right side. 1 is the angle between ACAL and MCAL, 2 is the angle between ACAR and MCAR, 3—the angle between ACAL and PcoAL, 4—the angle between ACAR and PcoAR, 5—the angle between ICAL and PcoAL, 6—the angle between ICAR and PcoAR, 7—the angle between PCAL and PCAR. (b): The cross-sectional planes.

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  Figure 3. CFD simulation results for one of animals: (a) Pressure distribution on the wall of the circulatory system, (b) Stream lines of the velocity vector, (c) Velocity field on cross-sectional planes: №2, №12, №13.

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  Figure 4. PLS-DA results: (a) steady calculation, (b) transient calculation. Groups of animals: 1, 2—the duration of the experiment in months, (c)—control, (d)—diabetes. Values are presented as mean \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\pm $$\end{document}± SE.