Key result
Review highlights molecular pathways of insulin resistance and current and emerging therapeutics.
Why the study?
Insulin resistance affects glucose and lipid metabolism through multiple molecular and intracellular pathways that have been recently elucidated.
This review provides an overview of the pathophysiology of insulin resistance and its effects on glucose and lipid metabolism, along with current and future therapeutic options.
Insulin resistance is a metabolic state encountered in many physiological and physiopathological conditions. Its pivotal effect on glucose and lipid metabolism is increasingly recognised. Over the last few years, numerous molecular/intracellular pathways affected by this condition have been elucidated. The author reviews some recent findings underlying several major metabolic abnormalities. An overview of current and future therapeutics is also provided.
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A 2001 study conducted a review in Insulin resistance. This review summarizes recent findings on the molecular pathways of insulin resistance, its effects on glucose and lipid metabolism, and provides an overview of current and future therapeutics.
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