Key result
Sympathetic tone exerts dominant control over resting heart rate in neonatal primates.
Why the study?
Autonomic control of resting heart rate in neonatal Rhesus monkeys and its differences from adults was not well characterized.
In neonatal Rhesus monkeys, the sympathetic nervous system has a dominant influence on resting heart rate, which contrasts with the parasympathetic dominance seen in adults.
Answers are grounded in this paper and cite their sources.
Neonatal primate HR falls post-restraint via dual autonomic input with sympathetic dominance; leaves open translation to human infants.
Autonomic control of resting heart rate was assessed using atropine and propranolol in 20 neonatal (2 to 3 weeks old) male Rhesus monkeys. After release from restraint for placement of a venous catheter, the average heart rate significantly decreased from 220 +/- 7 beats/min to 181 +/- 6 beats/min within 15 minutes and remained stable for the 2 hours. Autonomic control of resting heart rate is mediated through both divisions of the autonomic nervous system with the sympathetic system having a dominant influence. This is in contrast to the adult Rhesus, where the parasympathetic nervous system controls resting heart rate.
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Goldberg et al. (1985) studied this question. Atropine and propranolol was evaluated on Resting heart rate. Autonomic control of resting heart rate in neonatal Rhesus monkeys is mediated by both autonomic divisions, with the sympathetic system having a dominant influence.
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